Aging is inevitable, but that doesn’t mean you can’t take steps to keep your skin looking its best. With the right ingredients, you can maintain hydration, reduce fine lines, and improve texture—all without breaking the bank. Here are seven powerful over-the-counter (OTC) ingredients backed by science to help rejuvenate your skin after 40.

1. Hyaluronic Acid: The Ultimate Hydrator

Hyaluronic acid (HA) draws moisture into the skin, instantly plumping it and reducing the appearance of fine lines. It’s gentle enough for daily use and works well with other skincare products. For best results, apply an HA serum to damp skin, then lock it in with a moisturizer. Some research even suggests oral supplements may further enhance its wrinkle-reducing effects.

2. Ceramides: The Barrier Protectors

With age, our skin’s natural ceramides decline, leading to dryness and irritation. Products containing ceramides help restore the skin’s moisture barrier, preventing water loss and keeping skin supple. Look for fragrance-free creams with ceramide NP or EOP for maximum effectiveness, and apply them nightly for deep hydration.

3. Retinol: The Wrinkle Fighter

Retinol accelerates cell turnover and boosts collagen production, making it a powerhouse against wrinkles. Start with a low concentration (0.03% or less) to test tolerance, then gradually increase usage. Avoid sensitive areas like under the eyes unless the formula is designed for delicate skin. Be patient—results take time, but the payoff is smoother, firmer skin.

4. Ferulic Acid: The Antioxidant Booster

Found naturally in plants, ferulic acid enhances the effects of other antioxidants like vitamin C and vitamin E. It helps even skin tone and calms irritation. Use a serum with a 0.5% to 3% concentration, preferably combined with vitamin C for brightening benefits. Always store it in opaque packaging to maintain potency.

5. Lactic Acid: The Gentle Exfoliator

Unlike harsher acids, lactic acid exfoliates while hydrating, making it ideal for mature skin. A 10% concentration works well for most people, but beginners should start with once or twice weekly applications. Avoid pairing it with physical scrubs or retinol to prevent irritation. Over time, lactic acid helps fade discoloration and improve firmness.

6. Vitamin C: The Brightening Powerhouse

Vitamin C stimulates collagen, defends against sun damage, and evens skin tone. A concentration of 8% to 15% with a low pH ensures effectiveness without daily application. Choose dark or airtight packaging to prevent oxidation, and apply it in the morning before sunscreen for optimal protection.

7. Omega Fatty Acids: The Soothing Hydrators

Omega-3, 6, and 9 fatty acids soothe irritation, lock in moisture, and provide light UV protection. They’re gentle enough for daily use, but if you’re acne-prone, avoid formulas with pore-clogging oils like olive or rosehip. Look for blends in serums or moisturizers alongside ceramides for extra nourishment.

Crafting Your Personalized Routine

The key to effective anti-aging skincare is tailoring your regimen to your skin’s needs. If irritation is a concern, combine hydrating ceramides and omega fatty acids with occasional lactic acid treatments. For more aggressive rejuvenation, try retinol paired with ferulic acid and vitamin C.

Consistency is key—give each ingredient time to work, and always protect your skin with SPF during the day. With the right approach, you can embrace aging gracefully while keeping your complexion radiant and healthy.